146 research outputs found
A System Appallingly out of Balance : Morgan v. State and the Rights of Defendants and Victims in Sexual Assault Prosecutions
In a series of three cases that culminate with Morgan v. State, Alaska\u27s courts established a unique protection for defendants in sexual assault cases. This protection, which allows such defendants to attack their victims in court with previous reports of sexual assault that did not result in prosecution, is not afforded to defendants in other cases and is based on a dubious general principle that the credibility of sexual assault victims has special relevance. The protection is problematic in several ways: it is grounded in erroneous stereotypes about the victims of sex crimes; it is detrimental to victims and the pursuit of truth; it is inconsistent with traditional rules of evidence; and it is unnecessary to protect the rights of defendants. For these reasons, this protection for defendants in sexual assault cases should be abrogated by legislative action as proposed herein
Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment.
Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE. Therefore, a better understanding of the signals controlling migration of neutrophils as well as evaluating the role of these cells in demyelination is important to define cellular components that contribute to disease in MS patients. In this study, we examined the functional role of the chemokine CXCL1 in contributing to neuroinflammation and demyelination in EAE. Using transgenic mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells, we have shown that sustained CXCL1 expression within the CNS increased the severity of clinical and histologic disease that was independent of an increase in the frequency of encephalitogenic Th1 and Th17 cells. Rather, disease was associated with enhanced recruitment of CD11b+ Ly6G+ neutrophils into the spinal cord. Targeting neutrophils resulted in a reduction in demyelination arguing for a role for these cells in myelin damage. Collectively, these findings emphasize that CXCL1-mediated attraction of neutrophils into the CNS augments demyelination suggesting that this signaling pathway may offer new targets for therapeutic intervention
Chemical differentiation in regions of high-mass star formation I. CS, dust and N2H^+ in southern sources
Aims. Our goals are to compare the CS, N2H+ and dust distributions in a
representative sample of high-mass star forming dense cores and to determine
the physical and chemical properties of these cores. Methods. We compare the
results of CS(5-4) and 1.2 mm continuum mapping of twelve dense cores from the
southern hemisphere presented in this work, in combination with our previous
N2H+(1-0) and CS(2-1) data. We use numerical modeling of molecular excitation
to estimate physical parameters of the cores. Results. Most of the maps have
several emission peaks (clumps). We derive basic physical parameters of the
clumps and estimate CS and N2H+ abundances. Masses calculated from LVG
densities are higher than CS virial masses and masses derived from continuum
data, implying small-scale clumpiness of the cores. For most of the objects,
the CS and continuum peaks are close to the IRAS point source positions. The
CS(5-4) intensities correlate with continuum fluxes per beam in all cases, but
only in five cases with the N2H+(1-0) intensities. The study of spatial
variations of molecular integrated intensity ratios to continuum fluxes reveals
that I(N2H+)/F{1.2} ratios drop towards the CS peaks for most of the sources,
which can be due to a N2H+ abundance decrease. For CS(5-4), the I(CS)/F{1.2}
ratios show no clear trends with distance from the CS peaks, while for CS(2-1)
such ratios drop towards these peaks. Possible explanations of these results
are considered. The analysis of normalized velocity differences between CS and
N2H+ lines has not revealed indications of systematic motions towards CS peaks.Comment: 13 pages, 5 figures, accepted by Astronomy and Astrophysic
Water in massive star-forming regions: HIFI observations of W3 IRS5
We present Herschel observations of the water molecule in the massive
star-forming region W3 IRS5. The o-H17O 110-101, p-H18O 111-000, p-H2O 22
202-111, p-H2O 111-000, o-H2O 221-212, and o-H2O 212-101 lines, covering a
frequency range from 552 up to 1669 GHz, have been detected at high spectral
resolution with HIFI. The water lines in W3 IRS5 show well-defined
high-velocity wings that indicate a clear contribution by outflows. Moreover,
the systematically blue-shifted absorption in the H2O lines suggests expansion,
presumably driven by the outflow. No infall signatures are detected. The p-H2O
111-000 and o-H2O 212-101 lines show absorption from the cold material (T ~ 10
K) in which the high-mass protostellar envelope is embedded. One-dimensional
radiative transfer models are used to estimate water abundances and to further
study the kinematics of the region. We show that the emission in the rare
isotopologues comes directly from the inner parts of the envelope (T > 100 K)
where water ices in the dust mantles evaporate and the gas-phase abundance
increases. The resulting jump in the water abundance (with a constant inner
abundance of 10^{-4}) is needed to reproduce the o-H17O 110-101 and p-H18O
111-000 spectra in our models. We estimate water abundances of 10^{-8} to
10^{-9} in the outer parts of the envelope (T < 100 K). The possibility of two
protostellar objects contributing to the emission is discussed.Comment: Accepted for publication in the A&A HIFI special issu
Herschel-HIFI detections of hydrides towards AFGL 2591 (Envelope emission versus tenuous cloud absorption)
The Heterodyne Instrument for the Far Infrared (HIFI) onboard the Herschel
Space Observatory allows the first observations of light diatomic molecules at
high spectral resolution and in multiple transitions. Here, we report deep
integrations using HIFI in different lines of hydrides towards the high-mass
star forming region AFGL 2591. Detected are CH, CH+, NH, OH+, H2O+, while NH+
and SH+ have not been detected. All molecules except for CH and CH+ are seen in
absorption with low excitation temperatures and at velocities different from
the systemic velocity of the protostellar envelope. Surprisingly, the CH(JF,P =
3/2_2,- - 1/2_1,+) and CH+(J = 1 - 0, J = 2 - 1) lines are detected in emission
at the systemic velocity. We can assign the absorption features to a foreground
cloud and an outflow lobe, while the CH and CH+ emission stems from the
envelope. The observed abundance and excitation of CH and CH+ can be explained
in the scenario of FUV irradiated outflow walls, where a cavity etched out by
the outflow allows protostellar FUV photons to irradiate and heat the envelope
at larger distances driving the chemical reactions that produce these
molecules.Comment: Accepted for publication in Astronomy and Astrophysics (HIFI first
results issue
HERSCHEL-HIFI spectroscopy of the intermediate mass protostar NGC7129 FIRS 2
HERSCHEL-HIFI observations of water from the intermediate mass protostar
NGC7129 FIRS 2 provide a powerful diagnostic of the physical conditions in this
star formation environment. Six spectral settings, covering four H216O and two
H218O lines, were observed and all but one H218O line were detected. The four
H2 16 O lines discussed here share a similar morphology: a narrower, \approx 6
km/s, component centered slightly redward of the systemic velocity of NGC7129
FIRS 2 and a much broader, \approx 25 km/s component centered blueward and
likely associated with powerful outflows. The narrower components are
consistent with emission from water arising in the envelope around the
intermediate mass protostar, and the abundance of H2O is constrained to \approx
10-7 for the outer envelope. Additionally, the presence of a narrow
self-absorption component for the lowest energy lines is likely due to
self-absorption from colder water in the outer envelope. The broader component,
where the H2O/CO relative abundance is found to be \approx 0.2, appears to be
tracing the same energetic region that produces strong CO emission at high J.Comment: 6 pages, 4 figures, accepted by A&
Water in Star-Forming Regions with the Herschel Space Observatory (WISH): Overview of key program and first results
`Water In Star-forming regions with Herschel' (WISH) is a key program on the
Herschel Space Observatory designed to probe the physical and chemical
structure of young stellar objects using water and related molecules and to
follow the water abundance from collapsing clouds to planet-forming disks.
About 80 sources are targeted covering a wide range of luminosities and
evolutionary stages, from cold pre-stellar cores to warm protostellar envelopes
and outflows to disks around young stars. Both the HIFI and PACS instruments
are used to observe a variety of lines of H2O, H218O and chemically related
species. An overview of the scientific motivation and observational strategy of
the program is given together with the modeling approach and analysis tools
that have been developed. Initial science results are presented. These include
a lack of water in cold gas at abundances that are lower than most predictions,
strong water emission from shocks in protostellar environments, the importance
of UV radiation in heating the gas along outflow walls across the full range of
luminosities, and surprisingly widespread detection of the chemically related
hydrides OH+ and H2O+ in outflows and foreground gas. Quantitative estimates of
the energy budget indicate that H2O is generally not the dominant coolant in
the warm dense gas associated with protostars. Very deep limits on the cold
gaseous water reservoir in the outer regions of protoplanetary disks are
obtained which have profound implications for our understanding of grain growth
and mixing in disks.Comment: 71 pages, 10 figures, PASP, in pres
Anomalous Fluctuations of Directed Polymers in Random Media
A systematic analysis of large scale fluctuations in the low temperature
pinned phase of a directed polymer in a random potential is described. These
fluctuations come from rare regions with nearly degenerate ``ground states''.
The probability distribution of their sizes is found to have a power law tail.
The rare regions in the tail dominate much of the physics. The analysis
presented here takes advantage of the mapping to the noisy-Burgers' equation.
It complements a phenomenological description of glassy phases based on a
scaling picture of droplet excitations and a recent variational approach with
``broken replica symmetry''. It is argued that the power law distribution of
large thermally active excitations is a consequence of the continuous
statistical ``tilt'' symmetry of the directed polymer, the breaking of which
gives rise to the large active excitations in a manner analogous to the
appearance of Goldstone modes in pure systems with a broken continuous
symmetry.Comment: 59 pages including 8 figures ( REVTEX 3.0 )E-mail:
[email protected]
Hydrides in Young Stellar Objects: Radiation tracers in a protostar-disk-outflow system
Context: Hydrides of the most abundant heavier elements are fundamental
molecules in cosmic chemistry. Some of them trace gas irradiated by UV or
X-rays. Aims: We explore the abundances of major hydrides in W3 IRS5, a
prototypical region of high-mass star formation. Methods: W3 IRS5 was observed
by HIFI on the Herschel Space Observatory with deep integration (about 2500 s)
in 8 spectral regions. Results: The target lines including CH, NH, H3O+, and
the new molecules SH+, H2O+, and OH+ are detected. The H2O+ and OH+ J=1-0 lines
are found mostly in absorption, but also appear to exhibit weak emission
(P-Cyg-like). Emission requires high density, thus originates most likely near
the protostar. This is corroborated by the absence of line shifts relative to
the young stellar object (YSO). In addition, H2O+ and OH+ also contain strong
absorption components at a velocity shifted relative to W3 IRS5, which are
attributed to foreground clouds. Conclusions: The molecular column densities
derived from observations correlate well with the predictions of a model that
assumes the main emission region is in outflow walls, heated and irradiated by
protostellar UV radiation.Comment: Astronomy and Astrophysics Letters, in pres
Sensitive limits on the abundance of cold water vapor in the DM Tau protoplanetary disk
We performed a sensitive search for the ground-state emission lines of ortho-
and para-water vapor in the DM Tau protoplanetary disk using the Herschel/HIFI
instrument. No strong lines are detected down to 3sigma levels in 0.5 km/s
channels of 4.2 mK for the 1_{10}--1_{01} line and 12.6 mK for the
1_{11}--0_{00} line. We report a very tentative detection, however, of the
1_{10}--1_{01} line in the Wide Band Spectrometer, with a strength of
T_{mb}=2.7 mK, a width of 5.6 km/s and an integrated intensity of 16.0 mK km/s.
The latter constitutes a 6sigma detection. Regardless of the reality of this
tentative detection, model calculations indicate that our sensitive limits on
the line strengths preclude efficient desorption of water in the UV illuminated
regions of the disk. We hypothesize that more than 95-99% of the water ice is
locked up in coagulated grains that have settled to the midplane.Comment: 5 pages, 3 figures. Accepted for publication in the Herschel HIFI
special issue of A&
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